Prostate epithelial cells carry Beta-estrogen receptors (ERB) that when activated by isoflavones, genistein, act as tumor suppressors in prostate carcinogenesis by inhibiting invasion, proliferation of carcinoma cells & increasing apoptosis (programmed cell death). ERB also prevents prostate cancer by preventing the rapidly differentiating prostatic epithelial cells from undergoing oncogenic transformation. Genistein, the main phytoestrogen in soy, inhibits metastasis at levels that are equal to what you would find when eating soy.
I have been an athlete all my life & an endurance athlete for the past 9 years. Recently I started to question: what is the best diet for endurance sports? How can I maximize efficiency & energy production and improve recovery & decrease inflammation?
A recent meta-analysis showed that omega 3 fatty acid supplementation had no significant association with fatal or nonfatal coronary heart disease or any major vascular event. I know this is contrary to what we have heard over the years. It is estimated that over 20 million Americans take fish oil supplements daily but is it necessary?
I remember how I use to shovel any type of food in my mouth that looked good. I thought disease was based solely on genetics and that what we ate had nothing to do with chronic disease or cancer. What if I told you it is actually a combination of both …
Exercise is one of the leading ways to improve your health, decrease mortality, prevent cardiovascular disease, and prevent age-related physical and cognitive decline. BUT … Exercise shouldn’t be used as a mechanism for weight loss. Exercise alone will not help you lose weight long term for two primary reasons ....
...but red cabbage isn’t only a pretty cruciferous veggie! Cabbage is high in cyanidin, ascorbic acid, carotenoids, phylloquinone, tocopherol, and 21 anthocyanins including the phenolic compounds p-coumaric, ferric, and synaptic acid! Now these may just seem like useless words, but their bioactive properties are endless! One study showed that when mice were fed a high-fat diet with red cabbage or red cabbage microgreens there was a drastic reduction in LDL, VLDL, hepatic cholesterol, triglyceride levels and a reduced expression of inflammatory markers in the liver, namely CRP and TNF-alpha - this is most likely caused by an increase in the cytochrome p450 enzyme 7A1 or other anti-inflammatory and antioxidant properties.
I get this question all the time - but doesn't soy contain estrogen? Doesn't soy lower your testosterone? Doesn't soy give you man boobs ... You think I am joking - I literally get this a few times a week! Soy is a staple for many cultures and has played an important role in the diets of East Asian countries for centuries. In each gram of soy, you will find roughly 3.5mg of Isoflavones - diphenolic compounds and a class of phytoestrogens that are selective estrogen receptor modulators. Before you jump to conclusions you should know: there are different isoforms of estrogen receptors, with opposite functions, and there are different phytoestrogens that each modulate different estrogen receptor isoforms to varying degrees. (yeah, it is more complex than even I thought) Now, the two primary isoflavones in soybeans are genistein and daidzein. For a good review on their roles on other tissues in the body, I recommend reading the entire review in the Nutrients Journal. In the review, Scientist Mark Messina, who has dedicated his life and reputation to studying soy, put together a 42 page article on how soy may reduce the risk of coronary heart disease, breast cancer and prostate cancer, why soy alleviates hot flashes and may beneficially effect renal function, alleviate depressive symptoms, and improve skin health. He also reviews the studies showing that isoflavones do not adversely affect the breast, thyroid, or uterus of post menopausal women. (Note: Soy, just like anti-acids and calcium supplements, may interview with thyroid hormone replacement therapies, but it does not effect or cause hypothyroidism). Now, the question at hand ...
I can not say I always knew what they were, but about 5 years I discovered this amazing root at the store! At first I just thought it was a colorful sweet potato, until I started doing some research! Purple sweet potatoes are high in the flavonoids: cyanidnin and peonidin. These two anthocyanin have been shown to reduce inflammation by lowering COX-2 levels, MCP-1, and IL-6! For my friends in medicine, we know these inflammatory markers all too well! At first I was skeptical, I figured all the studies were in vitro with 1000x concentrations, but to my relief there are human studies showing the effects on participants’ metabolic factors, hepatic function tests, and inflammatory markers.
From the literature that we have, and our current understanding, walnuts slow the growth of malignant tumors. Now they don’t prevent malignant cells from forming, but they slow the growth of tumors and suppress cancer stem cell growth through gene expression changes and pro-apoptotic pathways.
Chronic exposure to calorie dense foods, typically in the form of a standard high-fat diet, causes metabolic stress effecting mitochondrial respiration and dissipation of the mitochondrial proton gradient in adipose tissue causing mitochondrial dysfunction. Previously we knew that anthocyanin-rich diets were beneficial for maintaining healthy body weight, improving glucose and lipid metabolism, and determining inflammatory status of key metabolic tissues. The anthocyanins, malvidin, petunidin, and peonidin (in berries) were found to improve body composition and enhance mitochondrial respiration and dissipation of the mitochondrial protein gradient when under chronic metabolic stress.