Chronic exposure to calorie dense foods, typically in the form of a standard high-fat diet, causes metabolic stress effecting mitochondrial respiration and dissipation of the mitochondrial proton gradient in adipose tissue causing mitochondrial dysfunction. Previously we knew that anthocyanin-rich diets were beneficial for maintaining healthy body weight, improving glucose and lipid metabolism, and determining inflammatory status of key metabolic tissues. The anthocyanins, malvidin, petunidin, and peonidin (in berries) were found to improve body composition and enhance mitochondrial respiration and dissipation of the mitochondrial protein gradient when under chronic metabolic stress.
Glaucoma, the leading cause of blindness in the world, is from optic nerve and retinal ganglion cell damage resulting in vision field loss most likely caused by increased intraocular pressure (IOP), blood flow abnormalities, oxidative stress and potentially autoimmune processes. For years, researchers speculated that coffee/tea could increase glaucoma risk because caffeine potentially increases IOP and homocysteine levels. In this study, researchers looked at the correlation of different beverage consumption and glaucoma prevalence from the National health and nutrition examination survey.
You all know I love my exercise, but is it ever too late for someone to start? Exercise, as you know, has played a huge role in my life! I exercise ever single day, without fail, BUT you do not have to go to those extremes to see lasting effects! For sedentary individuals, the heart undergoes a number of changes that ultimately can lead to heart failure. The development of heart failure, with a preserved ejection fraction, is likely mediated through increased left ventricular stiffness - a consequence of sedentary aging. In the study shown in the second image, sedentary adults were able to improve their maximal oxygen uptake and decrease the cardiac stiffness potentially protecting against the future risk of heart failure by preventing the increase in cardiac stiffness with 2 years of supervised high-intensity training.
"Don’t try to fake it until you make it, believe it until you become it - remember a professional is just an amateur who never quit."
“What you are capable of doing is not dictated by what you have done, what you are capable of doing is dictated by what you are willing to do.”
And while there is a small, yet subtle, difference in wording - the framework and context of how we set up our goals and aspirations shapes how we work day in and day out. At the end of the day, I don't want to just be a Dr. I don't just want the title of being a doctor. I want to embody what it means to be a physician. I want to be a doctor to my friends, my patients, my family, to the community around me, and everyone I come in contact with. Yes, I still have a long way to go to be a board certified physician, but I can work day-in and day-out to serve as an example of what it means to truly be a physician. A doctor isn't what I do, A doctor is who I am.
Every day I run, I have use the time to meditate and reflect on how I can improve as a person. How can I be a better husband, a better brother, a better friend, a better scientist, a better medical student, a better podcast host, etc. Everyday I will report back with what I have learned or discovered. Growing, during a physical challenge, is only as useful as the lessons you learn and the lessons you take away from it. So today...